Dissolving Filler Safe? Everything You Should Know in 2025

Filler injections have become one of the most popular cosmetic procedures in recent years—used to contour, volumize, and enhance facial features. However, not every result turns out as expected. Some individuals may experience lumps, swelling, or facial imbalance, prompting the need to dissolve filler either for correction or to return to a more natural appearance.

This comprehensive guide provides essential information about filler dissolving, including the methods, safety considerations, possible side effects, and how to choose the right clinic. Whether you’re looking to “reset” your face or simply exploring your options, this article will help you make an informed and confident decision.

What Is Filler Dissolving?

What Is Filler, and Why Would It Need to Be Dissolved?

Filler—most commonly referring to hyaluronic acid (HA) dermal fillers—is widely used in aesthetic treatments to restore volume, smooth out wrinkles, and enhance facial contours. HA is a naturally occurring substance in the body and is gradually broken down over time, typically lasting between 6 to 18 months depending on the product type, treatment area, and aftercare.

Despite its popularity, filler complications can arise. These may include filler migration, lump formation, asymmetry, or overfilling from repeated treatments without proper evaluation. In such cases, filler dissolving becomes a recommended option to reverse or correct the results, restoring the face to a more natural appearance.

What Does “Filler Dissolving” Involve?

Filler dissolving refers to the injection of an enzyme called Hyaluronidase, which breaks down HA-based fillers previously administered into the skin. This enzyme works by disrupting the molecular structure of hyaluronic acid, allowing the unwanted filler to dissolve and be naturally absorbed by the body.

Hyaluronidase is medically approved in many countries—including by the Thai FDA—and has been used for years in both aesthetic corrections and emergency cases such as vascular occlusion caused by filler injections.

Key Facts to Know Before Getting Filler Dissolved

• This procedure only works with HA fillers. It cannot dissolve permanent fillers like silicone or polymer-based products.
• A qualified medical professional should evaluate the case before administering Hyaluronidase.
• The dosage and concentration depend on the filler type and the severity of the issue.
• Mild swelling, redness, or stinging may occur post-injection, but these are typically temporary.
• Initial results may be seen within 24 to 72 hours following the treatment.

What Is Hyaluronidase and How Is It Used to Dissolve Filler?

What Is Hyaluronidase?

Hyaluronidase is a medical-grade enzyme designed to break down hyaluronic acid (HA)—the primary component found in most aesthetic dermal fillers. When injected into areas containing HA-based filler, Hyaluronidase cleaves the bonds within the hyaluronic acid structure, allowing the filler to dissolve more quickly and be absorbed by the body.

Initially used in medical applications to enhance the absorption of certain medications, Hyaluronidase later gained widespread use in aesthetic medicine. Today, it is approved for use in correcting unwanted filler results as well as in emergency situations, such as vascular occlusion caused by filler injection.

How Hyaluronidase Is Used in Filler Dissolving

• It works only on HA-based fillers—not on permanent fillers like silicone or PMMA.
• Doctors must assess the type, volume, and depth of the filler before treatment.
• The required amount of Hyaluronidase varies depending on the case.
• Results usually begin to show within 24 to 72 hours after the procedure.

What Types of Fillers Can Be Dissolved?

Dissolvable Fillers

Only hyaluronic acid (HA)-based fillers can be effectively dissolved using the enzyme Hyaluronidase. These are the most commonly used dermal fillers in aesthetic medicine because they are safe, reversible, and deliver natural-looking results.

Common dissolvable HA filler brands include:

• Juvederm®
• Restylane®
• Belotero®
• Neuramis®
• Revanesse®, and others.

Fillers That Cannot Be Dissolved with Hyaluronidase

• Permanent fillers such as liquid silicone, PMMA (polymethyl methacrylate), or unregulated synthetic substances
• Any filler not made from HA or adulterated with unknown components, especially in black-market or non-FDA-approved products

These types of fillers cannot be broken down with Hyaluronidase and may require surgical removal or specialized intervention.

How to Tell What Type of Filler You Have

• Ask your provider for the exact product name or packaging
• Confirm whether it’s labeled as an HA filler
• If unknown, a clinical evaluation or imaging may be required

Why Would Someone Need to Dissolve Filler?

Common Reasons for Filler Dissolving

While filler is generally safe and effective when administered by trained professionals, there are situations where patients may seek correction due to unwanted outcomes. These include:

• Lumps or uneven texture after filler settles
• Migration of filler to unintended areas (e.g., under eyes, temples, or lips)
• Facial features look unnatural or dramatically altered
• Overfilling due to repeated treatments over time
• Personal dissatisfaction or desire to restore the original facial contours

Urgent Medical Reasons

• Vascular occlusion (VO): A serious condition where filler blocks a blood vessel, requiring immediate dissolving to prevent tissue damage or necrosis.
• Severe allergic reactions to HA fillers—rare, but possible.

Dissolving to Correct, Not to Harm

Dissolving filler is not about “removing everything.” Rather, it’s a targeted correction guided by professional judgment. Physicians use Hyaluronidase strategically to dissolve problematic areas while preserving overall harmony. This makes it possible to re-treat or recontour in the future if desired.

When Should Filler Dissolving Be Avoided?

Situations Where Dissolving May Not Be Appropriate

Although Hyaluronidase is generally safe when administered by qualified professionals, there are specific situations where filler dissolving is not recommended or should be approached with caution:

• Unknown filler type: If the type of filler is unclear or not confirmed to be HA-based, Hyaluronidase may not work and could lead to unnecessary risks.
• Allergy to Hyaluronidase: Patients with a known allergy to this enzyme—or a history of hypersensitivity to multiple medications—should be skin-tested or avoid treatment.
• Pregnancy or breastfeeding: While no definitive contraindication has been proven, most doctors advise avoiding elective procedures during this period.
• Treatment by non-medical personnel: Filler dissolving must be performed only by licensed medical professionals with proper training in facial anatomy and medication use.

Physician’s Advice

If you are unsure about the type of filler you’ve received, a thorough consultation with an experienced doctor is essential. Accurate diagnosis ensures safety and success in correction.

Is Filler Dissolving Painful and How Long Does It Take?

What Does It Feel Like?

Most patients report that filler dissolving is minimally painful, especially when a topical numbing cream or local anesthetic is used before the procedure.

Some individuals may experience a mild stinging or burning sensation as the Hyaluronidase is injected, which is normal and usually subsides shortly after the treatment.

How Long Does the Procedure Take?

• The actual injection process typically takes 10 to 20 minutes, depending on the treatment area and volume.
• No downtime is required; patients can return home immediately.
• Mild swelling or redness may occur but usually resolves within 1 to 3 days.
• Visible results may begin to appear within 24 to 72 hours, with full effects settling in about a week.

What Is the Process for Filler Dissolving?

Before the Procedure

• A consultation with the doctor is required to assess the issue and confirm whether the injected filler is HA-based.
• If the filler type is unknown, the doctor may request prior medical records or use diagnostic tools.
• A patch test for Hyaluronidase allergy may be performed, especially for patients with a history of allergic reactions.

During the Procedure

1. Facial cleansing is performed, followed by the application of a topical anesthetic.
2. The doctor injects Hyaluronidase into the targeted area using specific techniques to dissolve only the undesired filler.
3. Gentle massage may be done to distribute the enzyme evenly for better breakdown.

After the Procedure

• Patients can go home immediately after treatment.
• Avoid makeup in the treated area for at least 24 hours.
• Refrain from touching or massaging the area with pressure.
• A follow-up appointment is typically scheduled within a week to assess results.

Post-Dissolving Care: Do’s & Don’ts

What You Should Do (Do’s)

• Apply a cold compress gently to the treated area within the first 24 hours to reduce swelling and redness.
• Clean your face gently, avoiding scrubbing or harsh rubbing.
• Stay well-hydrated by drinking plenty of water to support healing.
• Attend follow-up appointments as scheduled, especially if you’re planning future filler treatments.

What You Should Avoid (Don’ts)

• Avoid massaging or pressing the treated area for at least 48 hours.
• Stay away from heat exposure such as saunas, hot baths, or steam rooms for 72 hours.
• Refrain from intense physical activity or vigorous exercise for 1–2 days.
• Avoid applying makeup or heavy skincare on the injected area within the first 24 hours.

Additional Advice

If you experience any unusual symptoms such as excessive swelling, severe pain, or spreading redness, contact your doctor immediately to rule out complications.

Will My Face Return to Normal After Dissolving?

What to Expect After Dissolving

One of the most common concerns patients have is: “Will my face look the same as before?” The answer depends on several factors:

• Amount of filler previously injected: Heavily filled areas may show a more noticeable change after dissolving.
• Injection site: Areas like the under-eyes or chin may affect facial contour visibly once filler is removed.
• Duration since the filler was placed: Long-term fillers may cause minor tissue changes.

Does the Face Change After Dissolving?

• In most cases, the face returns to a close approximation of its pre-filler appearance, especially with HA fillers that haven’t fully integrated.
• Some patients may need 1–2 weeks for tissue to settle after the procedure.
• If residual filler remains, additional dissolving may be recommended.

Professional Assessment Matters

A qualified doctor can evaluate whether full or partial dissolving is appropriate and explain the expected outcomes clearly—so you won’t face any unwanted surprises.

When Can I Get Filler Again After Dissolving?

Recommended Waiting Period

After receiving Hyaluronidase, most doctors recommend waiting at least 7 to 14 days before considering new filler injections. This allows time for:

• The enzyme to fully break down existing filler
• The tissue to heal and settle
• Minimizing the risk of unintentionally dissolving new filler

Factors That May Affect Timing

• Amount and area of dissolved filler: Larger or multiple treatment areas may require more time.
• Post-dissolving inflammation or swelling: Active irritation must subside before reinjection.
• Desired aesthetic goals: The new filler plan may differ based on how your face adjusts post-dissolving.

Always Reassess with a Doctor First

Before undergoing new filler treatment, your provider should re-evaluate your facial anatomy and recommend the best approach to avoid overcorrection or repeating past issues.

Are There Any Side Effects from Filler Dissolving?

Common Side Effects

Filler dissolving with Hyaluronidase is generally safe, but some temporary side effects may occur, such as:

• Mild swelling, redness, or stinging at the injection site
• Bruising or discoloration, typically resolving within 3–7 days
• Temporary volume loss or uneven texture, especially in areas with large filler amounts
• Slight skin sensitivity or tightness in some individuals

Rare Complications

• Allergic reactions to Hyaluronidase: Very rare, but a patch test is advised for those with known sensitivities
• Unintended degradation of natural HA: If injected inaccurately, it may affect the body’s natural hyaluronic acid

How to Minimize Risks

• Get treated by a licensed, experienced medical provider
• Avoid unregulated clinics or practitioners without medical credentials
• Always disclose your medical history and allergies beforehand

Emergency Cases: When Immediate Dissolving Is Needed

Critical Situations Requiring Urgent Dissolving

In some cases, filler complications may require immediate intervention with Hyaluronidase to prevent serious consequences:

• Vascular Occlusion (VO) Symptoms include sudden intense pain, blanching or purple skin, and numbness. If not treated promptly, VO may lead to tissue necrosis or even permanent vision loss.
• Nerve Compression Symptoms include tingling or prolonged sharp pain in the injection area.
• Abnormal hard lumps or filler accumulation appearing rapidly post-injection.

Warning Signs That Require Medical Attention

• Sudden burning or throbbing pain after filler injection
• Skin color changing from red to purple or gray
• Rapid swelling or spreading inflammation
• Visual disturbances such as blurred vision or dark spots

Why Acting Fast Matters

Time is critical in emergencies. When Hyaluronidase is administered within 4–6 hours of symptom onset, it can significantly reduce the risk of permanent damage or long-term complications.

How Soon Will I See Results After Filler Dissolving?

Expected Timeline

After Hyaluronidase is injected, most patients begin to see noticeable changes within:

• 24 to 72 hours: Filler starts to visibly reduce
• By day 7: The effects stabilize, and tissues begin to settle
• In some cases, full results take 10 to 14 days to fully integrate

Factors That Influence Results

• Type and amount of filler previously injected
• Depth and location of the filler
• Individual response to the enzyme
• Injection technique used by the provider

What If Filler Isn’t Fully Dissolved?

In some cases—especially with large or deep injections—a second dissolving session may be recommended after 1–2 weeks to completely remove any remaining product.

How Much Does Filler Dissolving Cost?

Estimated Cost in Thailand (2025 Update)

• Starting from 3,000–6,000 THB per area, or
• Charged by unit or vial of Hyaluronidase (e.g., 1 vial per treated zone)

Costs may vary depending on the complexity of the case, amount of filler, and treatment location.

Factors Affecting Cost

• Treatment area: Delicate zones like the under-eye typically require advanced techniques and may cost more.
• Amount of enzyme needed: Larger filler volumes may require multiple vials.
• Doctor’s expertise: Highly experienced injectors often charge higher fees.
• Diagnostic assessments: Some clinics include ultrasound scanning to analyze filler before dissolving.

Recommendation

Never choose based solely on price. Prioritize licensed clinics with transparent medication sources and qualified doctors for your safety.

How to Choose a Safe Clinic for Filler Dissolving

5 Key Factors to Check Before Booking

1. Licensed Medical Doctor (MD) on Site
   • Verify the doctor’s name and credentials via the Medical Council of Thailand.
2. Clinic Licensed by the Ministry of Public Health
   • Look for an official license number visibly displayed at the premises.
3. Only Thai FDA-Approved Hyaluronidase Is Used
   • Brands like Hyalase® or Liporase® with complete packaging.
4. Clear Explanation of the Procedure
   • Including dosage, injection sites, and expected results.
5. Proper Aftercare and Follow-up
   • Post-treatment assessments and accessible support channels for concerns.

Watch Out for Misleading Claims

Avoid clinics that advertise with phrases like “100% instant results” or “one shot fixes everything.” These may indicate a lack of medical understanding or regulatory compliance.

FAQ: Common Questions About Filler Dissolving

Q: What types of fillers cannot be dissolved?

A: Permanent fillers like liquid silicone, PMMA, or any non-HA substances cannot be broken down with Hyaluronidase.

Q: Do I need a skin test before every Hyaluronidase injection?

A: Not for everyone—but it’s recommended if you have a history of allergies or haven’t had Hyaluronidase before.

Q: Can Hyaluronidase dissolve my body’s natural HA?

A: Slightly, in the treated area—but the body naturally regenerates HA within a few days.

Q: Can filler reappear after dissolving?

A: No. Once dissolved, the filler does not return unless you get another injection.

Q: Will my face sag or look worse after dissolving?

A: Not if done properly. With the right dosage and technique, your face should return close to its pre-filler state without looking tired or saggy.

Dissolving vs. Surgical Removal: What’s the Difference?

Summary

• For HA fillers and urgent corrections, dissolving is fast and effective.
• For permanent or highly distorted fillers, surgery may be the only option.

Summary: Who Should Consider Filler Dissolving?

Who Is It For?

• Individuals whose facial proportions feel unnatural or distorted
• Those experiencing lumps, swelling, firmness, or migration after filler
• People wanting to reset their face before new filler planning
• Patients with urgent complications like vascular occlusion
• Anyone uncertain about the type or safety of previously injected fillers

What Should You Know First?

• Only HA fillers can be dissolved with Hyaluronidase
• Must be performed by a licensed doctor using FDA-approved medication
• Some cases may require multiple sessions
• Wait at least 1–2 weeks post-dissolving before reinjection

Why Medical Planning Matters

Filler dissolving isn’t just a technical procedure—it requires expert assessment of facial structure and a personalized plan to achieve balanced, safe results.