If you’re searching for a way to restore your skin’s strength, smoothness, and natural glow, Rejuran could be one of the most effective options available today. This injectable treatment has gained wide recognition in dermatology for its ability not only to reduce wrinkles and acne scars but also to repair the skin’s structure from within.
In this article, you’ll discover everything you need to know about Rejuran—from how it works and the different formulations, to pre- and post-treatment care, and how it compares to other popular treatments—so you can make a confident, well-informed decision.
Rejuran is a skin-rejuvenation treatment developed using high-purity Polynucleotides (PN) extracted from salmon DNA. Its key strength lies in repairing skin at the cellular level, stimulating regeneration, and strengthening the dermal structure from within.
The treatment works by restoring the extracellular matrix (ECM) — a crucial skin component that deteriorates with age and sun exposure — without over-hydrating or increasing sebum production. This allows the skin to heal in a balanced, natural way.
One of Rejuran’s notable properties is its high biocompatibility with human skin. This is due to the structural similarity between salmon DNA and human DNA, along with a purification process that removes proteins that could trigger allergic reactions.
Rejuran is officially approved by the Korea Food and Drug Administration (KFDA) and is widely used in top dermatology clinics across Asia, especially in South Korea and Singapore.
Rejuran is available in three main formulations, each designed to target specific skin concerns. Here’s a breakdown of the most commonly used types:
This all-purpose formula is used to revitalize overall skin health—ideal for dullness, large pores, fine lines, and weakened skin. It helps strengthen the skin barrier, improve elasticity, and restore a youthful glow. Recommended for early signs of aging or sun damage.
Formulated specifically to treat acne scars, this version is more viscous, allowing it to fill shallow to moderate scars without using dermal fillers. It is applied in a targeted fashion to areas with atrophic scarring.
Tailored for the delicate under-eye area, this formula is lightweight and gentle. It targets fine lines, dryness, and dark circles with minimal swelling or discomfort after injection.
Each type contains different levels of Polynucleotides and viscosity to suit the injection site and treatment goal. In many cases, a dermatologist may combine more than one formula to achieve optimal results across the face.
Rejuran stands out not just as a skin treatment but as a true regenerative therapy that focuses on restoring the skin’s structure at its foundation. The core component, Polynucleotide (PN), plays a critical role in repairing damaged skin cells — going beyond superficial hydration.
One of Rejuran’s most important benefits is its ability to revive the extracellular matrix (ECM), the internal scaffold that supports skin structure. This stimulates collagen production, enhances elasticity, and strengthens the skin naturally without the use of fillers or energy-based devices.
Visible improvements from ECM repair include firmer skin, refined texture, minimized pores, and softened fine lines — all achieved through a natural, internal healing process.
Because of this, Rejuran has become a preferred solution among dermatologists, particularly for patients seeking results that are subtle, natural-looking, and appropriate for skin that has been over-treated or weakened by harsh procedures.
Rejuran is ideal for individuals with weakened or aging skin, especially those experiencing:
The best time to start Rejuran is typically from age 25 and above, when natural collagen production begins to decline noticeably and the skin loses its resilience.
Rejuran is also a great option for those whose skin has been overexposed to energy-based treatments like lasers or RF, which may thin the skin or increase sensitivity. Since Rejuran works without heat or energy, it helps “reset” the skin’s balance gently and safely.
While Rejuran is safe and effective for all skin types, it’s particularly beneficial for those with specific concerns
Although Rejuran isn’t a hydrating filler like hyaluronic acid, it improves the skin’s ability to retain moisture by restoring internal structure. Ideal for people whose skin feels dry at a deep level, beyond what topical moisturizers can fix.
For those with oily areas (e.g., T-zone) yet feel tight or dry after cleansing, Rejuran helps restore ECM balance—reducing excess sebum without clogging pores.
Thanks to its biocompatibility, Rejuran is very low-risk for irritation, making it suitable for people with sensitive or allergy-prone skin.
Skin that has undergone multiple energy-based treatments may become fragile. Rejuran helps rebuild skin strength without introducing additional heat or stress.
Rejuran is not just a surface-level aesthetic treatment—it’s designed to restore skin health from within, addressing root causes of damage. It offers notable improvements for several common concerns
The Polynucleotides in Rejuran stimulate collagen production, visibly softening fine lines, especially around the forehead, eyes, and nasolabial folds caused by repeated facial movements.
Rejuran S is formulated to help repair atrophic acne scars by promoting skin regeneration and filling in surface irregularities—without the need for dermal fillers.
By repairing the ECM, Rejuran tightens the skin from within, leading to smaller-looking pores and a smoother, more even complexion that holds makeup better.
For those suffering from persistent dullness due to fatigue or lifestyle stress, Rejuran restores vitality and brightness to the skin by enhancing cellular function.
While many skin treatments offer short-term improvements, Rejuran stands out for its regenerative mechanism that focuses on internal skin repair rather than surface-level enhancements. Here’s how it compares to other popular options:
| Treatment | Mechanism | Strengths | Notes |
|---|---|---|---|
| Rejuran | Repairs ECM and stimulates cell regeneration | Improves skin structure and resilience from within | Gradual results; requires consistent sessions |
| Skin Booster (HA) | Infuses Hyaluronic Acid for hydration | Instant plumpness and glow | Temporary results; no structural repair |
| Meso Therapy | Delivers vitamins and antioxidants | Brightens dull skin in the short term | Limited to superficial effects |
| Exosome | Signals skin to repair and regenerate | Innovative; works on multiple layers | Higher cost; requires multiple sessions |
| Gouri | Liquid PCL to induce collagen synthesis | Firming and volumizing effect | Not suitable for inflamed or sensitive skin |
Rejuran is highly versatile and can be safely combined with other aesthetic procedures — when guided by a qualified physician. This is especially beneficial for patients seeking comprehensive skin rejuvenation across multiple dimensions: firmness, hydration, and brightness.
Although compatible, Rejuran should be spaced 1–2 weeks apart from energy-based treatments (e.g., lasers or HIFU) to minimize overstimulation during the skin’s recovery phase.
A typical Rejuran session takes about 45–60 minutes and involves a straightforward, well-tolerated process. Here are the general steps:
Although Rejuran is a no-downtime procedure, the first 48–72 hours post-treatment are crucial for deep skin recovery. Proper aftercare helps reduce side effects and optimizes treatment outcomes.
The cost of Rejuran treatments in aesthetic clinics typically ranges from 5,000 to 15,000 THB per session, depending on the formulation used, dosage, and the expertise of the practitioner. Key pricing factors include:
The standard dose is usually 1 cc, but more may be needed for broader areas, which affects the total cost.
More experienced doctors may charge higher fees, but this often translates into better technique and safer results.
Clinics that use authentic products from licensed distributors and offer reliable aftercare tend to charge accordingly for quality and safety.
Tip: If the price seems unusually low, it’s essential to verify product authenticity.
Rejuran is considered a very safe procedure, primarily because it uses purified Polynucleotides (PN) derived from salmon DNA, which are highly biocompatible with human skin. However, like any injectable treatment, there are mild and temporary side effects that may occur:
Most side effects from Rejuran are mild and self-limiting, especially when the procedure is performed by a trained medical professional using authentic, sterile products.
A common question is: “When will I see results after Rejuran?” Unlike fillers or Botox, Rejuran works gradually by repairing the skin from within through natural regeneration, not instant volumization.
Does Rejuran hurt?
Not significantly. A numbing cream is applied for 30–45 minutes beforehand, and most patients report only mild discomfort—like tiny pinpricks. The sensation is tolerable and resolves quickly.
How long does a Rejuran session take?
The full procedure takes about 45–60 minutes, including cleansing, numbing, and injection time.
Can men get Rejuran?
Absolutely. It’s ideal for men with concerns like enlarged pores, acne scars, or dull skin. Rejuran helps restore a healthy, firm look without altering masculine features.
At what age should someone start Rejuran?
Generally from age 25 onward, as this is when collagen production begins to decline and signs of skin aging become more visible.
Can I wear makeup after Rejuran?
Avoid makeup for at least 24 hours post-treatment to allow the skin to recover and prevent irritation or clogged pores.
Rejuran isn’t just a beauty trend—it’s a science-backed skin therapy designed for those who seek natural, downtime-free rejuvenation with real structural benefits. It offers a powerful solution for skin weakened by age or environmental stress.
If you’re looking to rebuild your skin’s integrity, smoothness, and youthful glow from within, Rejuran could be the long-term answer—as long as it’s done under the care of an experienced medical professional.
